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In the 12 weeks prior to screening, the participants drank alcohol on three-quarters of the days included in that time frame, and they drank heavily on more than half of the days.
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The new trial included 93 participants, ages 25 to 65, who had been diagnosed with alcohol dependence based on criteria in the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-4) in the newer DSM-5, the condition would be classified as alcohol use disorder. in this issue of JAMA Psychiatry reflects a rekindling of interest in the use of hallucinogens to treat AUD, an approach that, despite its early promise, has been quiescent for half a century," Kranzler and Hartwell wrote. However, political pressures soon brought such psychedelic research to a grinding halt, Nature News reported (opens in new tab).
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Henry Kranzler, director of the Center for Studies of Addiction at the University of Pennsylvania (UPenn) Perelman School of Medicine, and Emily Hartwell, a clinical psychologist at UPenn, who were not involved in the trial, wrote in a commentary (opens in new tab) also published in JAMA Psychiatry.Īlthough relatively small, those early LSD trials hinted that the trip-inducing drug could help patients reduce their alcohol consumption and avoid the negative consequences of alcohol use more effectively than placebo pills or stimulants, such as ephedrine or amphetamine, could. The idea of using psychedelics to treat alcohol use disorder (AUD) dates to the 1960s and 1970s, when scientists began testing LSD (lysergic acid diethylamide) for this purpose, Dr. "If these effects hold up in future trials, psilocybin could be a breakthrough in the treatment of alcohol use disorder," he said. Michael Bogenschutz, lead study author and the director of the NYU Langone Center for Psychedelic Medicine, said at the news conference. The therapeutic effects of psilocybin and therapy were "considerably larger" than those reported for existing drugs used to treat alcohol use disorder, and it's "remarkable" that the effects persisted for months after treatment, Dr. Related: 'Magic mushroom' compound may work just as well as antidepressants, small study finds